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Absolute stereochemistry of the highly mutagenic 7,8-diol 9,10-epoxides derived from the potent carcinogen trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene

✍ Scribed by Yagi, H.; Akagi, H.; Thakker, D. R.; Mah, H. D.; Koreeda, M.; Jerina, D. M.

Book ID
120183332
Publisher
American Chemical Society
Year
1977
Tongue
English
Weight
283 KB
Volume
99
Category
Article
ISSN
0002-7863

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📜 SIMILAR VOLUMES

Labeled metabolites of polycyclic aromat
Labeled metabolites of polycyclic aromatic hydrocarbons. V. trans-7,8-dihydrobenzo[a]pyrene-7,8-diol-7-14C and (±)-7α,8β-dihydroxy-9β,10β-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene-7-14C
✍ Daniel J. McCaustland; W. P. Duncan; James F. Engel 📂 Article 📅 1976 🏛 John Wiley and Sons 🌐 French ⚖ 245 KB

## Abstract trans‐7,8‐Dihydrobenzo[a]pyrene‐7,8‐diol‐7‐^14^C (VI) and (±)‐7α,8β‐dihydroxy‐9β,10β‐epoxy‐7,8,9,10‐tetrahydrobenzo[a]‐pyrene‐7‐^14^C (VII) were prepared at a specific activity of 53.9 mCi/mmole by a multi‐step synthetic sequence using K^14^CN as the labeled precursor. The overall radio

Labeled metabolites of polycyclic aromat
Labeled metabolites of polycyclic aromatic hydrocarbons. VI. Trans-7,8-dihydrobenzo[a]pyrene-7,8,diol-G-3H and (±)-7α,8β-dihydroxy-9β,10β-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene-G-3H
✍ Daniel J. McCaustland; Daniel L. Fischer; W. P. Duncan; Edward J. Ogilvie; James 📂 Article 📅 1976 🏛 John Wiley and Sons 🌐 French ⚖ 294 KB

## Abstract The syntheses of trans‐7,8‐dihydrobenzo[a]pyrene‐7,8‐diol‐G‐^3^H (V) and (±)‐7α, 8β‐dihydroxy‐9β,10β‐epoxy‐7,8,9,10‐tetrahydrobenzo[a]pyrene‐G‐^3^H (VI) are described. The specific activities of V and VI were 158 mCi/mmole and 220 mCi/mmole, respectively. The key intermediate, trans‐7,8