Absolute configuration of (+)-trans-2-o-tolylcyclohexanol by X-ray crystallography

✍ Scribed by Arthur Camerman; Lyle H. Jensen; Todd G. Cochran; Alain C. Huitric

• Publisher: John Wiley and Sons
• Year: 1970
• Tongue: English
• Weight: 219 KB
• Volume: 59
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600591133

✦ Synopsis

indoles, this is not the situation, as may be seen in Figs. . These substances have K;l values; other pertinent information is listed in Table .

CONCLUSION

The stoichiometry of the complex has not been delineated, but slopes of less than one as encountered in Figs. 1-3 imply a 1 : 1 complex. This does not prove the absence of other complex species (16).

Table illustrates that all K,', values, including that of methysergide, are of approximately the same magnitude. This indicates that a good portion of the capacity for complexation of the high molecular weight ergot alkaloids lies within the indole moiety of the molecule. The role the cyclic tripeptide portion plays in the mutual attraction of caffeine and related xanthines for these proteinaceous alkaloids has yet to be spelled out; however, it is likely that these protein substituents may alter binding in some way.