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Absolute configuration of the enantiomers of 7-chloro-4-[[4-(diethylamino)-1-methylbutyl]amino]quinoline (chloroquine)

✍ Scribed by Craig, J. Cymerman; Bhargava, Hemendra N.; Everhart, E. Thomas; LaBelle, Bruce; Ohnsorge, Ulrich; Webster, Richard V.

Book ID
118165240
Publisher
American Chemical Society
Year
1988
Tongue
English
Weight
580 KB
Volume
53
Category
Article
ISSN
0022-3263

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πŸ“œ SIMILAR VOLUMES

Resolution of 7-chloro-4(4β€²-diethylamino
Resolution of 7-chloro-4(4β€²-diethylamino-1β€²methylbutyl)aminoquinoline (chloroquine) into its enantiomers
✍ Dr. J. Cymerman Craiga; Aslam M. Ansari πŸ“‚ Article πŸ“… 1993 πŸ› John Wiley and Sons 🌐 English βš– 300 KB

## Abstract Evidence is accumulating that 7‐chloro‐4‐[4‐diethylamino‐1‐methylbutyl] amino quinoline (chloroquine) displays considerable stereoselectivity in its metabolism, pharmacokinetics, macromolecular interactions, and biological activity. The availability of the enantiomers has been hampered

The absolute configuration of the enanti
The absolute configuration of the enantiomers of 6-chloro-9-(4β€²-diethylamino-1β€²-methylbutyl)-amino-2-methoxyacridine (quinacrine)
✍ J. Cymerman Craig; Bruce Labelle; Ulrich Ohnsorge πŸ“‚ Article πŸ“… 1991 πŸ› John Wiley and Sons 🌐 English βš– 176 KB

Absolute configurations have been assigned to the enantiomers of the antimalarial drug quinacrine dihydrochloride. Condensation of ( -)-(R)-4-amino-l-diethylaminopentane (from L-glutamic acid) with 6,9-dichloro-2-methoxyacridine gave ( -)-(R)-6-chloro-9-(4'diethylamino-1'-methylbutyl) amino-2-methox