Absolute configuration of 1-oxo[2.2]metacyclophane
โ Scribed by Mislow, Kurt.; Brzechffa, Magdalena.; Gschwend, Heinz W.; Puckett, Reginald T.
- Book ID
- 126438867
- Publisher
- American Chemical Society
- Year
- 1973
- Tongue
- English
- Weight
- 258 KB
- Volume
- 95
- Category
- Article
- ISSN
- 0002-7863
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๐ SIMILAR VOLUMES
## Abstract The title compound __2__ has been synthesized and its structure has been determined by Xโray analysis. The following crystal data were found: monoclinic, P2~1~, a = 9.936(4), b = 18.009(3), c = 10.418(3) ร , and ฮฒ = 107.22(3)ยฐ. Two molecules of the compound (two oxathiaphospholane anions
The l-azabicyclo[2.2. I]heptan-3-exo-ol (2) was resolved by fractional crystallisation of its hydrogen tartrate salts. The enantiomers (+)-and (-)-2 were oxidised to the ketones (-)-4 and (+)-4, respectively (Scheme). CD spectroscopy suggested that (-)-4 possesses the (IR,4S)-configuration. This abs