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Absolute Configuration and Anticancer Activity of Taxiresinol and Related Lignans of Taxus wallichiana.

✍ Scribed by Sunil K. Chattopadhyay; T. R. Santha Kumar; Prakas R. Maulik; Sachin Srivastava; Ankur Garg; Ashoke Sharon; Arvind S. Negi; Suman Preet S. Khanuja


Publisher
John Wiley and Sons
Year
2004
Weight
87 KB
Volume
35
Category
Article
ISSN
0931-7597

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Absolute configuration and biological ac
✍ Dr. Cristina Di Bugno; Paolo Dapporto; Raffaello Giorgi; Stefano Manzini; Paola 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 509 KB

## Abstract The enantiomers of 1‐methyl‐3‐(10__H__‐phenothiazine‐10‐ylmethyl)‐1‐azoniabicyclo[2,2,2]octane iodide (1) were prepared by chiral chromatographic resolution of the precursor mequitazine (2). The (+)‐(S)‐enantiomer 1b is 10‐fold more potent than (−)‐(R)‐enantiomer 1a as a histamine antag