Trisomy 15 is described as a common finding in all T-cell leukemias induced by a single dose of methylnitrosourea (MNU) in BDF, mice and in the leukemias induced by 7 doses of benzo(a)pyrene. Additional trisomies were found in about half of the leukemias. The organ distribution suggests that the leu
Absence of trisomy 15 in chemically induced murine T-cell lymphomas
β Scribed by Maureen Goodenow; Kevin Kessler; Leslie Leinwand; Frank Lilly
- Book ID
- 119103181
- Publisher
- Elsevier Science
- Year
- 1986
- Tongue
- English
- Weight
- 507 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0165-4608
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## Abstract Gβbanding analyses of 14 independently derived Bβcell lymphomas showed the frequent occurrence of chromosome 15 trisomy. It was present in seven of nine spontaneous Bβcell lymphomas, but in company with other trisomies, monosomies and marker chromosomes. In five carcinogenβinduced prima
Trisomy 15 is the most common chromosomal aberration in murine T-cell lymphomas. The relevant chromosomal region responsible for the growth advantage of the 15-trisomic cell has not been defined. In order to map this region, we have induced thymic lymphomas by chemical carcinogens (DMBA or MNU) in m
## Abstract The banding pattern of DMBAβinduced leukemias in C57BL/6 mice revealed a very constant chromosome pattern: the presence of trisomy 15 in almost all leukemic cells. This finding strongly suggests that chromosome 15 trisomy is the first detectable specific chromosome change associated wit