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Absence of Signs of Vitamin B12 - Nitrous Oxide Interaction in Operating Theatre Personnel

✍ Scribed by M. Salo; A. Rajamaki; J. Nikoskelainen


Book ID
115102690
Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
244 KB
Volume
28
Category
Article
ISSN
0001-5172

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Exposure to nitrous oxide interferes selectively with the coenzyme function of vitamin B12 and causes inactivation of methionine synthetase, with subsequent impairment of folate metabolism and reduction of cellular proliferation. In a rat leukemia model (BNML) we investigated the combined administra