## Background: The objective of the study was to evaluate the pathogenetic and prognostic value of p53 protein expression in squamous cell carcinoma of the vulva. ## Methods: The clinical data in charts of 167 patients with international federation of gynecology and obstetrics (figo) stages i-iii
Absence of p53 protein overexpression in precancerous lesions of the vulva
β Scribed by Petra D. Kohlberger; Reinhard Kirnbauer; Dagmar Bancher; Gerald Gitsch; Alexander Reinthaller; Sepp Leodolter; Erwin Tschachler; Christian Kainz; Gerhard Breitenecker
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 351 KB
- Volume
- 82
- Category
- Article
- ISSN
- 0008-543X
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β¦ Synopsis
BACKGROUND.
Recently the authors reported the prognostic value of p53 protein Petra D.
π SIMILAR VOLUMES
## RESULTS. DO7, an anti-p53 monoclonal antibody, showed p53 overexpression in 35 carcinomas (53%). Consensus primer PCR showed HPV infection in 12 carcinomas
Mutations of the tumor-suppressor gene p53 are common in epithelial tumors. Clonal mutations of p53 have been found in cervical and vulvar carcinomas negative for human papillomavirus (HPV), though at least in cervical cancer HPV infection and p53 mutations are not mutually exclusive. We have previo
We have previously reported overexpression of p53 protein in tobacco-related oral dysplasia and squamous cell carcinoma (SCC) in the Indian population. A follow-up study was carried out to determine the prognostic significance of an accumulation of p53 protein during oral tumorigenesis. One hundred