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Absence of nucleophosmin 1 (NPM1) gene mutations in common solid cancers

✍ Scribed by EUN GOO JEONG; SUNG HAK LEE; NAM JIN YOO; SUG HYUNG LEE


Book ID
109343655
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
120 KB
Volume
115
Category
Article
ISSN
0365-5555

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Nucleophosmin mutations of exon 12 (NPM1 mutations) represent the most frequent molecular aberration that can be found in patients with acute myeloid leukaemia (AML) and can be detected in about 35% of AML patients. NPM1 mutations are characterised by four basepair insertions within the region corre