## Abstract Gliomas are the most common tumors of the central nervous system and have a grave prognosis. Deletion of chromosome 10p15 is one of the most common chromosomal alterations in gliomas. Recently, a candidate tumor suppressor gene, __KLF6__, which is mapped to chromosome 10p, was found to
Absence of mutations in the putative tumor suppressor gene KLF6 in glioblastomas and meningiomas
✍ Scribed by Benjamin Köhler; Marietta Wolter; Britta Blaschke; Guido Reifenberger
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- French
- Weight
- 52 KB
- Volume
- 111
- Category
- Article
- ISSN
- 0020-7136
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Loss of heterozygosity (LOH) on chromosome 10 is the most common genetic changes in glioblastomas of World Health Organization (WHO) Grade IV. [1][2][3][4][5][6][7] In most cases, the allelic losses involve loci along the entire chromosome, a finding in line with monosomy 10. LOH on chromosome 10 ma
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