Absence of microsatellite instability in thyroid carcinomas
✍ Scribed by F. Vermiglio; M. Schlumberger; V. Lazar; I. Lefreré; B. Bressac
- Book ID
- 116166113
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 132 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0959-8049
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Microsatellite instability (MSI) has been reported to occur in a wide variety of sporadic tumours, such as colorectal and gastric cancers. MSI positivity has been associated with a particular clinico-pathologic profile, including the presence of abundant lymphoid infiltration, poor differentiation a
Microsatellite instability has been found preferentially in tumours associated with the hereditary non-polyposiscolorectal-cancer (HNPCC) syndrome. This phenotype, manifested as new alleles at microsatellite loci, and often the result of a defective mismatch-repair gene, is seen as allelic mobility