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Absence of MDM-2 gene amplification in experimentally induced tumors regardless of p53 status

✍ Scribed by Guillermo T. Saez; Maria R. Oliva; Ramon Mangues; Angel Pellicer

Book ID: 102946566
Publisher: John Wiley and Sons
Year: 1994
Tongue: English
Weight: 536 KB
Volume: 9
Category: Article
ISSN: 0899-1987
DOI: 10.1002/mc.2940090108

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

To assess the generality of the hypothesis that murine double‐minute‐2 (MDM‐2) gene amplification complements the absence of p53 mutation during tumor development, we analyzed 143 murine tumors induced by a variety of carcinogenic agents in two different mouse strains. Only three of 143 tumors showed p53 genetic alterations and none showed MDM‐2 amplification, indicating the existence of alternative pathways that permit tumor cells to bypass p53–MDM‐2 control. © 1994 Wiley‐Liss, Inc.

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