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Absence of manganese superoxide dismutase delays p53-induced tumor formation

✍ Scribed by Case, Adam J.; Domann, Frederick E.


Book ID
121988482
Publisher
Elsevier
Year
2014
Tongue
English
Weight
504 KB
Volume
2
Category
Article
ISSN
2213-2317

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## Abstract To assess the generality of the hypothesis that murine double‐minute‐2 (__MDM‐2__) gene amplification complements the absence of __p53__ mutation during tumor development, we analyzed 143 murine tumors induced by a variety of carcinogenic agents in two different mouse strains. Only thre