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Absence of linkage for schizophrenia on the short arm of chromosome 5 in multiplex Canadian families

✍ Scribed by King, Nicole; Bassett, Anne S.; Honer, William G.; Masellis, Mario; Kennedy, James L.

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 10 KB
Volume: 74
Category: Article
ISSN: 0148-7299
DOI: 10.1002/(sici)1096-8628(19970919)74:5<472::aid-ajmg2>3.0.co;2-q

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✦ Synopsis

A VNTR for the human dopamine transporter gene (DAT-1) has been localized to chromosome 5p15.3. Silverman et al. [1996] found evidence for genetic linkage of the D5S111 locus, located just centromeric to DAT-1, to schizophrenia and related disorders in a large Hispanic family. We evaluated five markers on 5p, including D5S111 and the DAT-1 VNTR, in five multiplex schizophrenic families, assuming autosomal dominant transmission (subjects assessed n = 122, DNAs available n = 96, individuals with schizophrenia and schizoaffective disorder n = 36, broader spectrum disorders n = 14). LOD scores were negative across all families for all markers tested, and overall LOD scores were strongly negative (<-2.0, = 0) across all five families for each of the markers typed. Thus, there is no evidence to support the linkage of markers in this region of chromosome 5 to schizophrenia in this sample of families. Am. J. Med. Genet. 74:472-474, 1997.

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