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Absence of host plasminogen activator inhibitor 1 prevents cancer invasion and vascularization

✍ Scribed by Bajou, K.; Noël, A.; Gerard, R.D.; Masson, V.; Brunner, N.; Holst-Hansen, C.; Skobe, M.; Fusenig, N.E.; Carmeliet, P.; Collen, D.

Book ID
109929912
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
899 KB
Volume
4
Category
Article
ISSN
1078-8956

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We used an immunohistochemical assay with an antigenretrieval technique to study plasminogen activator inhibitor type-I (PAL I) expression in paraffin-embedded breast tissue samples at different stages of malignant transformation. We detected PAI-I in 15/20 invasive tumors. In several cases staining