Absence of FLT3 and JAK2 (V617F) mutations in Langerhans cell histiocytosis
โ Scribed by Malak Abedalthagafi; Huimin Guo; Dan-Paul Hartmann; Metin Ozdemirli
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 84 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0145-2126
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Recently, the acquired mutation JAK2-V617F has been described in the majority of patients with myeloproliferative disorders (MPDs). In this study we evaluated its clinical and laboratory correlates in 166 patients with MPDs. The mutation was detected by allele-specific PCR in 119 patients: 81.4% (35
Background. Because prostaglandin (PG) E2 has been identified in the bone lesions of Langerhans cell histiocytosis (LCH), we speculated that indomethacin, a potent PG inhibitor, may be useful in patients with symptomatic LCH involving the bony skeleton. Procedure. We used indomethacin to treat patie