Absence of annexin I expression in B-cell non-Hodgkin's lymphomas and cell lines
β Scribed by Jamboor K Vishwanatha; Eric Salazar; Velliyur K Gopalakrishnan
- Book ID
- 115010602
- Publisher
- BioMed Central
- Year
- 2004
- Tongue
- English
- Weight
- 476 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1471-2407
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CD45 is a glycoprotein expressed in all lymphohemopoietic cells. Its expression increases during B-lymphocyte ontogeny. Few data are available about CD45 expression in the various types of low-grade B-cell non-Hodgkin's lymphomas (NHL). Low levels of CD45 have been reported in pathologic lymphocytes
Chromosomal abnormalities involving 3q27 have recently been associated with diffuse large B-cell lymphomas and, less frequently, with follicular lymphomas. Molecular studies have led to the identification of the BCL-6LAZ-3 gene, located at 3q27 and coding for a putative zinc-finger protein that migh