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Absence of a PDX-1 mutation and normal gastroduodenal immunohistology in a child with pancreatic agenesis

โœ Scribed by Verwest, Aart M.; Poelman, Marnix; Dinjens, Winand N.M.; Batstra, Manou R.; Oostra, Ben A.; Lequin, Maarten H.; Larsson, Lars-Inge; Aanstoot, Henk-Jan; Bruining, G. Jan; de Krijger, Ronald R.


Book ID
111656726
Publisher
Springer
Year
2000
Tongue
English
Weight
303 KB
Volume
437
Category
Article
ISSN
1432-2307

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## Abstract The Notch signaling pathway is an evolutionarily conserved signaling mechanism and mutations in its components disrupt cell fate specification and embryonic development in many organisms. To analyze the in vivo role of the __Notch3__ gene in mice, we created a deletion allele by gene ta