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Increased DNA Methylation and Decreased Expression of PDX-1 in Pancreatic Islets from Patients with Type 2 Diabetes

✍ Scribed by Yang, B. T.; Dayeh, T. A.; Volkov, P. A.; Kirkpatrick, C. L.; Malmgren, S.; Jing, X.; Renstrom, E.; Wollheim, C. B.; Nitert, M. D.; Ling, C.


Book ID
111690059
Publisher
Endocrine Society
Year
2012
Tongue
English
Weight
267 KB
Volume
26
Category
Article
ISSN
0888-8809

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## Background: The plasma cell differentiation antigen (pc-1) is an inhibitor of insulin receptor tyrosine kinase activity, and has been implicated in the pathogenesis of insulin resistance in type 2 diabetes. metformin increases peripheral insulin sensitivity and, therefore, we have studied the ef