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Abrogation of lung metastasis of human fibrosarcoma cells by ribozyme-mediated suppression of integrin α6 subunit expression

✍ Scribed by Hiroshi Yamamoto; Atsushi Irie; Yuji Fukushima; Takanori Ohnishi; Norio Arita; Toru Hayakawa; Kiyotoshi Sekiguchi

Book ID
102649975
Publisher
John Wiley and Sons
Year
1996
Tongue
French
Weight
754 KB
Volume
65
Category
Article
ISSN
0020-7136

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✦ Synopsis

The interaction of tumor cells with the basement membrane plays a crucial role in tumor metastasis. VIA-6 (a6p I) integrin is one of the major surface receptors for the basement mernbrane, specifically recognizing laminin. To study the role of VLA-6 integrin in tumor invasion and metastasis, we synthesized a ribozyme that selectively degrades the integrin a6 subunit mRNA. The catalytic activity of the ribozyme w a s verified by in vitro cleavage of a6 subunit mRNA. Introduction of 3To whom correspondence and reprint requests should be sent, at

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