Expression of the Integrin α5 Subunit in HT29 Colon Carcinoma Cells Suppresses Apoptosis Triggered by Serum Deprivation

De novo expression of the α5β1-fibronect

De novo expression of the α5β1-fibronectin receptor in HT29 colon-cancer cells reduces activity of c-src. Increase of c-src activity by attachment on febronectin

✍ Roland Schmidt; Michael Streit; Rolf Kaiser; Frank Herzberg; Michael Schirner; K 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 French ⚖ 228 KB 👁 1 views

Changes in integrin expression during malignant transformation have been observed in many tumors. Colon-carcinoma cells show reduced expression or even loss of the ␣5␤1 integrin compared to normal or adenoma cells. To determine the significance of absent ␣5␤1 integrin signaling, we transfected the c