𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Abnormalities of Renal Physiology in Systemic Sclerosis

✍ Scribed by Philip J. Clements; Peter A. Lachenbruch; Daniel E. Furst; Morton Maxwell; Gabriel Danovitch; Harold E. Paulus

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
753 KB
Volume
37
Category
Article
ISSN
0004-3591

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✦ Synopsis

To evaluate the prognostic value of measurements of renal plasma flow and circulating vasoactive hormones in patients with systemic sclerosis (SSc).

Methods. Renal plasma flow (para-aminohippurate [PAH] clearance) and levels of selected circulating hormones (plasma renin activity [PRA] and serum aldosterone and catecholamines) were assessed in 57 SSc patients under the following conditions: at rest, in response to cold, while in upright position, and in response to sodium depletion. Survival was assessed 10.7 years after testing (20 patients had died).

Results. Both unstimulated and stimulated PRA clearance rates were frequently elevated. Resting PAH clearances were usually abnormally low. PAH clearances and levels of aldosterone and catecholamines did not change during cold stimulation.

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