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Abnormalities of peripheral blood lymphocytes in HTLV-I associated myelopathy

✍ Scribed by Yasuto Itoyama; Sei-ichiro Minato; Jun-ichi Kira; Ikuo Goto; Hiroyuki Sato; Kazuo Okochi; Naoki Yamamoto

Book ID: 119106989
Publisher: Elsevier Science
Year: 1987
Tongue: English
Weight: 47 KB
Volume: 16
Category: Article
ISSN: 0165-5728
DOI: 10.1016/0165-5728(87)90254-2

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To estimate the replication of the human T-cell leukemia virus type I (HTLV-I) in patients with HTLV-I-associated myelopathy (HAM), or tropical spastic paraparesis (TSP), HTLV-I DNA integrated into lymphocyte genomes was analyzed by Southern blot hybridization. HTLV-I DNA was detected in 125 (82%) o