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Increased replication of HTLV-I in HTLV-I–associated myelopathy

✍ Scribed by Dr Mitsuaki Yoshida; Mitsuhiro Osame; Hisaomi Kawai; Masami Toita; Nanako Kuwasaki; Yoshihiko Nishida; Yukako Hiraki; Kouichi Takahashi; Koichiro Nomura; Shunro Sonoda; Nobutaka Eiraku; Shinji Ijichi; Koichiro Usuku

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
474 KB
Volume
26
Category
Article
ISSN
0364-5134

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✦ Synopsis

To estimate the replication of the human T-cell leukemia virus type I (HTLV-I) in patients with HTLV-I-associated myelopathy (HAM), or tropical spastic paraparesis (TSP), HTLV-I DNA integrated into lymphocyte genomes was analyzed by Southern blot hybridization. HTLV-I DNA was detected in 125 (82%) of 153 patients and most showed random integration. This incidence was much higher than the 29% found in asymptomatic carriers. Therefore, HAM/ TSP development is associated with a high level of HTLV-I replication. I n addition, lymphocytes from 3 patients with HAM/TSP showed monoclonal integration of HTLV-I DNA, indicating adult T-cell leukemia.

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