Abnormalities of chromosomes 1 and 11 in Wilms' tumor
โ Scribed by Edwin C. Douglass; Judith A. Wilimas; Alexander A. Green; A. Thomas Look
- Book ID
- 119103092
- Publisher
- Elsevier Science
- Year
- 1985
- Tongue
- English
- Weight
- 420 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0165-4608
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Wilms' tumor has served as a model of multiple genetic alterations in childhood cancer. This review summarizes work in our laboratory identifying several of these alterations. These include the localization to 11 p l 5 of an embryonal tumor suppressor gene and at least one gene for Beckwith-Wiedeman
Of 40 Wilms tumors with chromosome abnormalities, 6 were hypodiploid, 10 were pseudodiploid, 7 were hyperdiploid with 47 to 49 chromosomes, and 17 were hyperdiploid with 50 or more chromosomes, mostly including ฯฉ12. WT1 deletions/ mutations were found in one hypodiploid, eight pseudodiploid, and one