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Abnormal visual activation in Parkinson's disease patients

✍ Scribed by Ellison Fernando Cardoso; Felipe Fregni; Fernanda Martins Maia; Luciano M. Melo; João R. Sato; Antonio Cesário Cruz Jr.; Edno Tales Bianchi; Danilo Botelho Fernandes; Mário Luiz Ribeiro Monteiro; Egberto Reis Barbosa; Edson Amaro Jr.

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
200 KB
Volume
25
Category
Article
ISSN
0885-3185

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Among nonmotor symptoms observed in Parkinson's disease (PD) dysfunction in the visual system, including hallucinations, has a significant impact in their quality of life. To further explore the visual system in PD patients we designed two fMRI experiments comparing 18 healthy volunteers with 16 PD patients without visual complaints in two visual fMRI paradigms: the flickering checkerboard task and a facial perception paradigm. PD patients displayed a decreased activity in the primary visual cortex (Broadmann area 17) bilaterally as compared to healthy volunteers during flickering checkerboard task and increased activity in fusiform gyrus (Broadmann area 37) during facial perception paradigm. Our findings confirm the notion that PD patients show significant changes in the visual cortex system even before the visual symptoms are clinically evident. Further studies are necessary to evaluate the contribution of these abnormalities to the development visual symptoms in PD. © 2010 Movement Disorders Society

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