## Background: Endothelial cell dysfunction is an early feature of vascular disease and oxidative stress may be involved in its pathogenesis. ## Methods: Fifty-one children, adolescents and young people with type 1 diabetes with no clinical diabetic angiopathy, mean age+/-sd of 16+/-4 years, diab
β¦ LIBER β¦
Abnormal T-cell reactivities in childhood inflammatory demyelinating disease and type 1 diabetes
β Scribed by Brenda Banwell; Amit Bar-Or; Roy Cheung; Julia Kennedy; Lauren B. Krupp; Dorothy J. Becker; Hans-Michael Dosch
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 587 KB
- Volume
- 63
- Category
- Article
- ISSN
- 0364-5134
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## Abstract ## Background Type 1 diabetes (T1D) is characterised by loss of tolerance to betaβcell antigens, and the insulinβproducing betaβcells in the pancreatic islets are destroyed by the host's own immune system. Immunological risk factors associated with T1D are related to the defects in the