Cytogenetic studies of Hodgkin's disease (HD), in contrast t o those of non-Hodgkin's lymphoma (NHL), have been limited t o small numbers of cases with infrequently recurring aberrations, underscoring the need for additional studies in establishing a coherent cytogenetic picture of HD. Over a 6%-yea
Abnormal immunoregulation in remission Hodgkin disease
β Scribed by M. R. Hutchins; Dr. R. B. Slease; J. L. Murray; K. E. Gawith; P. N. Grozea
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- English
- Weight
- 649 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0361-8609
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Cytogenetic analysis was performed on lymph nodes or other tumor masses from 33 patients with Hodgkin's disease. Metaphase cells were obtained in 25 of the 33 cases. Analyzable abnormal clones were found in nine cases. Characteristic abnormalities included polyploidy and complex structural rearrange
Hodgkin and Reed-Sternberg cells are considered to represent the malignant fraction in Hodgkin's disease. Several studies have shown that the Hodgkin and Reed-Sternberg cells are chromosomally abnormal, but genetic data about the morphologically normal cell population in Hodgkin's disease are very l