𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Abnormal drug metabolism in rats after an inflammatory insult

✍ Scribed by M. W. Whitehouse

Book ID
105427417
Publisher
SP Birkhäuser Verlag Basel
Year
1973
Tongue
English
Weight
438 KB
Volume
3
Category
Article
ISSN
1420-908X

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Pharmacologic interventions after an LD5
Pharmacologic interventions after an LD50 cocaine insult in a chronically instrumented rat model: Are beta-blockers contraindicated?
✍ Marc Smith; Daniel Garner; James T Niemann 📂 Article 📅 1991 🏛 Elsevier Science 🌐 English ⚖ 480 KB

Study purpose: To evaluate drug management of acute cocaine toxicity in a new animal model. The study null hypothesis was that no drug would affect outcome compared w~th a placebo control. Model: Chronically instrumented, conscious, unrestrained rats subjected to an LDso dose (1.4 mg/lO0 g body wt)

Stereoselective metabolism of tazofelone
Stereoselective metabolism of tazofelone, an anti-inflammatory bowel disease agent, in rats and dogs and in human liver microsomes
✍ Michael P. Clay; Brenda R. Hanssen; Sekhar S. Surapaneni; Terry D. Lindstrom 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 181 KB 👁 3 views

Incubation of (R)-tazofelone and (S)-tazofelone in rat, dog, and human liver microsomes demonstrated that the (R)-tazofelone enantiomer was more rapidly metabolized, with two diastereomeric sulfoxides as the major metabolites formed in all three species. The two diasteresomers epimerized at physiolo

Metabolism of 5-hydroxytryptamine and le
Metabolism of 5-hydroxytryptamine and levels of tricyclic antidepressant drugs in rat brain after acute and chronic treatment
✍ Marijke Wijk; Jean-Jacques Meisch; Jakob Korf 📂 Article 📅 1977 🏛 Springer 🌐 English ⚖ 672 KB

Because tricyclic antidepressants (TAD) are usually given chronically to patients, both their acute and their chronic effects on 5-hydroxytryptamine (5-HT) metabolism were studied. The probenecid method was used and, in addition to 5-hydroxy-indoleacetic acid (5-HIAA), some other indole compounds in