Abnormal Dendritic Spines in Fragile X Knockout Mice: Maturation and Pruning Deficits
β Scribed by Thomas A. Comery, Jennifer B. Harris, Patrick J. Willems, Ben A. Oostra, Scott A. Irwin, Ivan Jeanne Weiler and William T. Greenough
- Book ID
- 123640689
- Publisher
- National Academy of Sciences
- Year
- 1997
- Tongue
- English
- Weight
- 713 KB
- Volume
- 94
- Category
- Article
- ISSN
- 0027-8424
- DOI
- 10.2307/42508
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π SIMILAR VOLUMES
Fragile-X syndrome is a common form of mental retardation resulting from the inability to produce the fragile-X mental retardation protein. The specific function of this protein is unknown; however, it has been proposed to play a role in developmental synaptic plasticity. Examination of human brain
## Abstract Carboxypeptidase E (CPE) is involved in maturation of neuropeptides and sorting of brainβderived neurotrophic factor (BDNF) to the regulated pathway for activityβdependent secretion from CNS neurons. CPE knockout (CPEβKO) mice have many neurological deficits, including deficits in learn