Abnormal change of p53 gene in gastric and precancerous lesions and APC gene deletion in gastric carcinoma and near tissues
β Scribed by Ying, Hao ;Jinkun, Zhang ;Cuiqiong, Yi ;Wei, Qian
- Publisher
- Springer-Verlag
- Year
- 1997
- Tongue
- English
- Weight
- 273 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0257-716X
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## Abstract Eβcadherin mutations are found in 50% of diffuseβtype gastric carcinoma, but not in intestinal gastric carcinoma. Because cellβcell adhesion mediated by Eβcadherin plays an important role in epithelial cell survival, Eβcadherin mutations could alter the apoptotic behavior of tumor cells
Loss of heterozygosity at 4 tumor-suppressor gene loci (pS3, apc, mcc and Rb) was investigated using polymerase chain reactions, in 49 esophageal squamous-cell carcinoma specimens from patients who had undergone curative resection. Mutations in the p53 gene within exons 5 to 8 were also examined. LO