Abnormal anti-viral immune response in mice is corrected in HLA-B27.2-transgenic mice
β Scribed by Femia Kievits; Wil Lokhorst; Pavol Ivanyi
- Book ID
- 102161904
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 393 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0014-2980
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The HLA-B27 transgene was introduced into mice of the B10 background with various H-2 haplotypes. High levels of B27 antigen were detected on the surface of peripheral-blood lymphocytes from mice homozygous for the H-2b, H-2f, H-2s, H-2p, H-2r and H-2k haplotypes. In contrast, cell-surface expressio
The level of HLA-B27 transgene expression on the cell surface is dependent on the host H-2 haplotype. Mice homozygous for the H-2 b, H-2 f, H-2 ~, H-2 p, n-2 r, and H-2 ~ haplotypes express B27 at high levels. An intermediate level of B27 expression is observed in H-2 ~ mice whereas low levels of B