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Ablation of the spindle assembly checkpoint by a compound targeting Mps1

✍ Scribed by Schmidt, Marc; Budirahardja, Yemima; Klompmaker, Rob; Medema, René H


Book ID
110032835
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
189 KB
Volume
6
Category
Article
ISSN
1469-221X

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p53 plays a critical role as a tumour-suppressor in restricting the proliferation of damaged cells, thus preventing formation of genetically altered cell clones. Its inactivation leads, in particular, to accumulation of polyploid and aneuploid cells. To elucidate the role of p53 in control of chromo