ABH-antigenicity of transitional cell carcinoma of the urinary bladder in patients subjected to topical chemoprophylaxis
✍ Scribed by Gerhard Jakse; Ferdinand Hofstädter; Udo Engelmann; Günther H. Jacobi
- Publisher
- Springer-Verlag
- Year
- 1983
- Tongue
- English
- Weight
- 409 KB
- Volume
- 1
- Category
- Article
- ISSN
- 0724-4983
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Spleen cells from BALB/c mice immunized with cells derived from transitional cell carcinomas (TCC) of the human urinary bladder were fused with mouse myeloma Sp 2/0 Ag14 cells. Monoclonal antibodies from six established hybridomas were investigated for specificity in a cell ELISA and in indirect imm
Mitomycin C was administered t o 21 patients with metastatic transitional cell carcinoma of the urinary bladder. O f these, 19 patients were evaluable. Objective response occurred in f o u r patients, or 21 %. Hemopoietic depression was common and was dose related. Nephrotoxicity related t o the dr