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Aberrations of the p53 tumor suppressor gene in human non-small cell carcinomas of the lung


Book ID
123049271
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
296 KB
Volume
10
Category
Article
ISSN
0169-5002

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Mutations in the p53 tumor suppressor ge
✍ William E. Pierceall; Tapas Mukhopadhyay; Leonard H. Goldberg; Honnavara N. Anan πŸ“‚ Article πŸ“… 1991 πŸ› John Wiley and Sons 🌐 English βš– 528 KB

In this study, we analyzed 10 human squamous cell carcinomas (SCCs) for alterations in the p53 tumor suppressor gene in exons 4 through 9 by single-strand conformation polymorphism (SSCP) analysis. We found that 2 of 10 SCCs displayed unusual SSCP alleles at exon 7 of the p53 gene. Subsequent clonin