Aberrant regulation of the IgH 3′ enhancer by c-myc in plasmacytoma cells
✍ Scribed by Velmurugesan Arulampalam; Patrick Grant; Lorenz Poellinger; Sven Pettersson
- Book ID
- 116097638
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 913 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0161-5890
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## Abstract Reciprocal translocations involving the immunoglobulin loci and the cellular oncogene __MYC__ are hallmark mutations of the human postgerminal center B cell neoplasm, Burkitt's lymphoma. They are occasionally found in other B cell lymphomas, as well. Translocations involving the heavy c
## Abstract Regulation of the rearranged and non‐rearranged c‐__myc__ expression was studied in murine cell hybrids (SBWI and SBWII) between plasmacytoma (S194) and T‐cell lymphoma (BWS147) cells. Expression of the rearranged c‐__myc__ of heterogeneous mRNA sizes (1.8 ∼ 2.4 kb) was markedly down‐re