Long-range oncogenic activation of Igh–c-myc translocations by the Igh 3′ regulatory region

In a model of immunoglobulin heavy-chain

In a model of immunoglobulin heavy-chain (IGH)/MYC translocation, the Igh 3′ regulatory region induces MYC expression at the immature stage of B cell development

✍ Yi Yan; Sung Sup Park; Siegfried Janz; Laurel A. Eckhardt 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 361 KB

## Abstract Reciprocal translocations involving the immunoglobulin loci and the cellular oncogene __MYC__ are hallmark mutations of the human postgerminal center B cell neoplasm, Burkitt's lymphoma. They are occasionally found in other B cell lymphomas, as well. Translocations involving the heavy c