Aberrant promoter methylation of the retinoic acid receptor alpha gene in acute promyelocytic leukemia
β Scribed by Chim, C-S; Wong, S-Y; Pang, A; Chu, P; Lau, J S; Wong, K-F; Kwong, Y-L
- Book ID
- 110056457
- Publisher
- Nature Publishing Group
- Year
- 2005
- Tongue
- English
- Weight
- 168 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0887-6924
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Acute promyelocytic leukemia is characterized by the reciprocal translocation of chromosomes 15 and 17. All-trans retinoic acid (ATRA) efficiently induces differentiation of the abnormal promyelocytes. In this study, we had used ATRA as the primary induction therapy for 17 newly diagnosed patients,
Treatment of the acute promyelocytic (APL) cell line NB4 with interferon alpha (IFN(alpha)), as well as IFN(beta) and gamma, results in an increased expression of the transcripts coding for retinoic-acid receptor type alpha (RAR(alpha)) and the leukemia-specific retinoic acid receptor PML-RAR. Trans