The idiotypic structures of the myeloma protein might be regarded as tumor-specific antigens. The present study was designed to map T-cell epitopes of the idiotypic myeloma protein to prove the existence of naturally occurring majorhistocompatibility-complex-dependent idiotype (peptide)specific T ce
Aberrant immunoglobulin (IG) heavy chain glycosilation in igg multiple myeloma (MM)
β Scribed by Aurer, I.; Lauc, G.; Rendic, D.; Labar, B.
- Book ID
- 123341107
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 172 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0959-8049
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Mouse myeloma cells were transfected with pSV2-gpt and pSV2-neo based immunoglobulin expression vectors. Double transfectants were selected using the xanthine-guanine phosphoribosyl transferase t gpt) and the neomycin (neo) selection marker genes. A broad distribution in the level of mouse-human chi
Cytogenetic studies have shown rearrangements of the Ig heavy chain (IGH) gene at 14q32 in 10-60% of patients with multiple myeloma (MM) or primary plasma cell leukemia (PCL). Analysis of MM patients and human myeloma cell lines (HMCL) using interphase fluorescence in situ hybridization (FISH) and m