High prevalence of immunoglobulin light chain gene aberrations as revealed by FISH in multiple myeloma and MGUS

High incidence of cryptic translocations

High incidence of cryptic translocations involving the Ig heavy chain gene in multiple myeloma, as shown by fluorescence in situ hybridization

✍ Hervé Avet-Loiseau; Christophe Brigaudeau; Nadine Morineau; Pascaline Talmant; J 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 214 KB 👁 2 views

Cytogenetic studies have shown rearrangements of the Ig heavy chain (IGH) gene at 14q32 in 10-60% of patients with multiple myeloma (MM) or primary plasma cell leukemia (PCL). Analysis of MM patients and human myeloma cell lines (HMCL) using interphase fluorescence in situ hybridization (FISH) and m