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Ab initio protein structure prediction

โœ Scribed by Corey Hardin; Taras V Pogorelov; Zaida Luthey-Schulten


Book ID
114314494
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
77 KB
Volume
12
Category
Article
ISSN
0959-440X

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As part of the third Critical Assessment of Structure Prediction meeting (CASP3), we predict the three-dimensional structures for 13 proteins using a hierarchical approach. First, all possible compact conformations of a protein sequence are enumerated using a highly simplified tetrahedral lattice mo

Ab initio protein structure prediction o
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To generate structures consistent with both the local and nonlocal interactions responsible for protein stability, 3 and 9 residue fragments of known structures with local sequences similar to the target sequence were assembled into complete tertiary structures using a Monte Carlo simulated annealin