AAV-mediated expression of CNTF promotes long-term survival and regeneration of adult rat retinal ganglion cells
β Scribed by Leaver, S G; Cui, Q; Plant, G W; Arulpragasam, A; Hisheh, S; Verhaagen, J; Harvey, A R
- Book ID
- 110039842
- Publisher
- Nature Publishing Group
- Year
- 2006
- Tongue
- English
- Weight
- 674 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0969-7128
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## Abstract We have investigated the differential mediators of the neurotrophic effects of intravitreal peripheral nerve grafting and lens injury on adult rat retinal ganglion cells (RGC). Lens injury and intravitreal peripheral nerve grafting both stimulated RGC neurite growth in vitro and axon re
Adult rat retinal ganglion cells (RGC) undergo degeneration after optic nerve transection. Studies have shown that exogenously applied neurotrophic factors such as brain-derived neurotrophic factor (BDNF) can attenuate axotomy-induced as well as developmental RGC death. Here, we examined whether gli