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A2A/D2 receptor heteromerization in a model of Parkinson's disease. Focus on striatal aminoacidergic signaling

✍ Scribed by Ferraro, Luca; Beggiato, Sarah; Tomasini, Maria Cristina; Fuxe, Kjell; Antonelli, Tiziana; Tanganelli, Sergio


Book ID
119210643
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
507 KB
Volume
1476
Category
Article
ISSN
0006-8993

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The time course of the loss in presynaptic dopamine transporters (DAT) and of the increase in postsynaptic dopamine D2 receptors (D2R) was studied in a rat model of Parkinson's disease. For this, in vitro autoradiographic experiments were performed in the striatum using (E)-N-(3-iodoprop-2-enyl)-2be