Phase I clinical trials are designed to identify an appropriate dose for experimentation in phase II and III studies. I present the results from a simulation study to evaluate the performance of nine phase I designs involving the standard design, the two-stage modified Storer's design, the two-stage
โฆ LIBER โฆ
A02 Evaluation of phase I cancer clinical trial designs
โ Scribed by Chul Ahn; Tamara Odom-Maryon; Joyce Niland; Akiko Chai
- Book ID
- 113298402
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 88 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0197-2456
No coin nor oath required. For personal study only.
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This note is a response to a recent paper by Korn et al. in which two phase I trial designs were compared, the designs in question being the standard design and the CRM design. The authors concluded that: (i) CRM designs will take longer to complete than standard designs; and (ii) CRM designs are le