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A Versatile Synthesis of 2-Alkyl and 2-Aryl 4-Quinolones

โœ Scribed by Chen, Bang-chi; Huang, Xian; Wang, Jin


Book ID
121657713
Publisher
Thieme Medical Publishers
Year
1987
Tongue
German
Weight
149 KB
Volume
1987
Category
Article
ISSN
0039-7881

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A versatile two-step synthesis of 2-alkyl-4-aminopyridines from commercially available cis-1-methoxy-1-buten-3-yne is described. Acylation of the yne derivative followed by amination and cyclization in ammonia produced the desired substituted pyridines in high yield.