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A versatile synthesis of 17-heteroaryl androstenes via palladium-mediated Suzuki cross-coupling with heteroaryl boronic acids

โœ Scribed by Jianping Chao; Yangzhi Ling; Xiaofeng Liu; Xuande Luo; A.M.H. Brodie


Book ID
116891933
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
170 KB
Volume
71
Category
Article
ISSN
0039-128X

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โœ Paul R Eastwood ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 114 KB

A simple preparation of cyclic vinyl boronates derived from the vinyl triflates of N-protected tetrahydropyridines is described. Suzuki coupling of the boronates with aryl bromides, iodides and triflates proceeds in good yield to give 4-aryl tetrahydropyridines.