2-, 3-, and 4-(Trifluoromethoxy)phenylli
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Eva Castagnetti; Manfred Schlosser
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Article
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2001
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John Wiley and Sons
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English
β 257 KB
Consecutive treatment of (trifluoromethoxy)benzene with sec-butyllithium and electrophilic reagents affords previously inaccessible ortho-substituted derivatives in generally excellent yields. 2-(Trifluoromethoxy)phenyllithium acts as the key intermediate. The 3-and 4-isomers can readily be generate