A two-locus model for familial Alzheimer's disease?

✍ Scribed by Dr. Fabio Macciardi; M. Cristina Cavallini

• Book ID: 102226112
• Publisher: John Wiley and Sons
• Year: 1993
• Tongue: English
• Weight: 265 KB
• Volume: 10
• Category: Article
• ISSN: 0741-0395
• DOI: 10.1002/gepi.1370100618

✦ Synopsis

The present findings for familial Alzheimer's disease suggest a possible linkage to gene(s) on chromosome 21 for the early onset form and to chromosome 19 for the late onset. Since these results are not unequivocal, possible alternative hypotheses include the effect of genetic heterogeneity or of an oligogenic model of segregation for FAD. @ 1993 Wiley-Liss, Inc.