𝔖 Bobbio Scriptorium
✦   LIBER   ✦

A two dose combined hepatitis A and B vaccine in Chinese youngsters

✍ Scribed by Lee, Shou-Dong; Chan, Cho-Yu; Yu, May-Ing; Wang, Yuan-Jen; Chang, Full-Young; Lo, Kwang-Juei; Safary, Assad

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
60 KB
Volume
59
Category
Article
ISSN
0146-6615

No coin nor oath required. For personal study only.

✦ Synopsis

This open, randomized study was conducted in healthy Chinese youngsters, aged between 10 and 19 years to compare the reactogenicity and immunogenicity of two vaccines: the combined vaccine against hepatitis A and B was administered in a two-dose schedule with the profile of the corresponding monovalent vaccines, while the concomitant vaccine was administered also on a two-dose schedule but simultaneously in opposite arms. All vaccinees had antibodies against hepatitis A (anti-HAV) after the 2-dose administration, whereas all but four in the first and two in the second group had protective titres against hepatitis B (anti-HBs). At month 7, the geometric mean titres for both antibodies were more than double for the group of subjects receiving the combined vaccine: 3,701 vs. 1,705 mIU/ml for the anti-HAV, and 1,524 vs. 720 mIU/ ml for the anti-HBs response. Injection site pain was the most commonly reported local symptom and headache was the most reported general symptom. It is concluded that this combined vaccine against hepatitis A and B, administered according to a two-dose schedule, is welltolerated and highly immunogenic.

πŸ“œ SIMILAR VOLUMES

Clinical and immunological investigation
Clinical and immunological investigation of a new combined hepatitis A and hepatitis B vaccine
✍ Prof. Dr. F. Ambrosch; G. Wiedermann; F. E. AndrΓ©; A. Delem; H. Gregor; H. Hofma πŸ“‚ Article πŸ“… 1994 πŸ› John Wiley and Sons 🌐 English βš– 411 KB

## Abstract As with hepatitis B vaccines, the recently developed hepatitis A vaccine is suitable not only for individual protection, but also for public health control measures. For introduction into routine immunisation programmes, however, hepatitis A vaccine should preferably be combined with ot

Antibody persistence and immune memory i
Antibody persistence and immune memory in adults, 15 years after a three-dose schedule of a combined hepatitis A and B vaccine
✍ P. Van Damme; G. Leroux-Roels; P. Crasta; M. Messier; J-M. Jacquet; K. Van Herck πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons 🌐 English βš– 102 KB

## Abstract A combined hepatitis A and B vaccine is available since 1996. Two separate open‐label primary studies evaluated the immunogenicity and safety of this hepatitis A and B vaccine (720 EI.U of HAV and 20 ¡g of HBsAg) in 306 healthy subjects aged 17–43 years who received three doses of the v

Immunogenicity of a five-microgram dose
Immunogenicity of a five-microgram dose of hepatitis B vaccine
✍ George Papaevangelou; Anastasia Roumeliotou-Karayannis; Charalambos Vissoulis; S πŸ“‚ Article πŸ“… 1985 πŸ› John Wiley and Sons 🌐 English βš– 291 KB

The immunogenicity of a 5-micrograms dose of vaccine (H-B-Vax, MSD) was evaluated in 50 young adults (17-19 years). Results were compared to our previous studies using similarly prepared vaccines using 20 micrograms and 10 micrograms per dose with the same trial protocol in a comparable population.

Immunogenic effect of hepatitis B vaccin
Immunogenic effect of hepatitis B vaccine in children: Comparison of two-and three-dose protocols
✍ Bernard Yvonnet; Pierre Coursaget; Eric Petat; Eric Tortey; Cheikh Diouf; Franci πŸ“‚ Article πŸ“… 1984 πŸ› John Wiley and Sons 🌐 English βš– 183 KB

The immunogenic effect of hepatitis B vaccine was evaluated in 183 seronegative infants from Senegal. Seventy-two seronegative infants received two 5-micrograms doses of vaccine at a two-month interval and 111 seronegative infants received three 5-micrograms doses at one-month intervals. All the chi

Hepatitis B vaccine: Immunogenicity and
Hepatitis B vaccine: Immunogenicity and follow-up including two year booster doses in high-risk health care personnel in a London teaching hospital
✍ Dr. Elizabeth A. Fagan; Philippa Tolley; Heather M. Smith; Roger Williams; Adria πŸ“‚ Article πŸ“… 1987 πŸ› John Wiley and Sons 🌐 English βš– 457 KB

One hundred forty-four adult health care personnel (aged 18-62 years, median 33 years) considered at high risk of future HBV infection were vaccinated with a plasma-derived hepatitis B vaccine (20 pg HBVax at 0, 1, and 6 months) and followed-up for 2 years. Anti-HBs was present in only 6.9% prior to