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A Triterpenoid and Sesquiterpenoids from the Resinous Exudates of Commiphora myrrha

โœ Scribed by Tao Shen; Wen-Zhu Wan; Xiao-Ning Wang; Hui-Qing Yuan; Mei Ji; Hong-Xiang Lou

Publisher
John Wiley and Sons
Year
2009
Tongue
German
Weight
244 KB
Volume
92
Category
Article
ISSN
0018-019X

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โœฆ Synopsis

Abstract

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A new 30(14โ†’13)abeoโ€dammarane triterpenoid, myrrhasin (1), a new 14(10โ†’1)abeoโ€eudesmane sesquiterpenoid, myrrhanolide A (2), and two new cadinane sesquiterpenoids, myrrhanolides B and C (3 and 4, resp.), as well as nine known sesquiterpenoids, 5โ€“13, were isolated from the resinous exudates of Commiphora myrrha. Their structures were determined on the basis of extensive MS and NMR spectroscopic analyses. The isolated compounds 1โ€“6 were evaluated for their cytotoxicity against the PC3 and DU145 human prostate tumor cell lines.

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Three known and one novel furanogermacrenes have been isolated from the resinous exudate of Commiphora h o l t z i a ~ Engl. The structures of the known compounds were determined by comparison of 'Hand "C-NMR spectra with those already published. The structure of the novel compound was determined as